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Related Experiment Videos

Serum prolactin levels during the menstrual cycle.

M Vekemans, P Delvoye, M L'Hermite

    The Journal of Clinical Endocrinology and Metabolism
    |May 1, 1977
    PubMed
    Summary

    Serum prolactin levels increase significantly during the late follicular phase and luteal phase of the menstrual cycle. These findings were consistent across different radioimmunoassay methods, aiding reproductive health research.

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    Area of Science:

    • Endocrinology
    • Reproductive Biology

    Background:

    • Serum prolactin levels fluctuate throughout the menstrual cycle.
    • Understanding these fluctuations is crucial for reproductive health and fertility studies.

    Purpose of the Study:

    • To investigate the pattern of serum prolactin during the menstrual cycle.
    • To compare results obtained from human and ovine radioimmunoassays.

    Main Methods:

    • Daily blood samples were collected over 51 menstrual cycles.
    • Serum prolactin was measured using homologous human and ovine radioimmunoassays.

    Main Results:

    • A significant increase in serum prolactin was observed during the late follicular phase, peaking with the LH surge.
    • Serum prolactin levels were higher in the luteal phase compared to the early follicular phase.
    • The ovine assay yielded higher average prolactin levels than the human assay.

    Conclusions:

    • Serum prolactin exhibits a distinct pattern during the menstrual cycle, similar to 17beta-estradiol.
    • Radioimmunoassay methodology can influence absolute prolactin level measurements.
    • These findings contribute to a better understanding of hormonal dynamics in the female reproductive cycle.

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