Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental spinal cord compression by epidural neoplasm.

Y Ushio, R Posner, J B Posner

    Neurology
    |May 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Correlations between perfusion MR imaging cerebral blood volume, microvessel quantification, and clinical outcome using stereotactic analysis in recurrent high-grade glioma.

    AJNR. American journal of neuroradiology·2011
    Same author

    Season of birth and risk of brain tumors in adults.

    Neurology·2004
    Same author

    Occupation and the risk of adult glioma in the United States.

    Cancer causes & control : CCC·2003
    Same author

    Les syndromes paranéoplasiques.

    Revue neurologique·2002
    Same author

    The photoreceptor cell-specific nuclear receptor is an autoantigen of paraneoplastic retinopathy.

    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society·2001
    Same author

    Brain tumors.

    Cancer chemotherapy and biological response modifiers·2001

    Researchers created a rat model for spinal cord compression, observing paraplegia and edema. Dexamethasone treatment effectively reduced both spinal cord edema and clinical symptoms in affected animals.

    Area of Science:

    • Neuroscience
    • Oncology
    • Pharmacology

    Background:

    • Spinal cord compression can lead to severe neurological deficits.
    • Understanding the mechanisms of compression-induced injury is crucial for developing treatments.

    Purpose of the Study:

    • To establish a reliable experimental model of spinal cord compression in rats.
    • To investigate the effects of dexamethasone on spinal cord edema and clinical symptoms in this model.

    Main Methods:

    • An experimental model of spinal cord compression was developed in rats by injecting tumor anterior to the T-12 vertebral body.
    • Spinal cord edema was assessed by measuring water content, horseradish peroxidase leakage, and histological examination.
    • Clinical symptoms of paraplegia were monitored, and the effects of dexamethasone treatment were evaluated.

    Related Experiment Videos

    Main Results:

    • Tumor growth led to spinal cord compression and paraplegia within 3 to 4 weeks.
    • Evidence of vasogenic edema, including increased water content and horseradish peroxidase leakage, was observed in the compressed spinal cord.
    • Dexamethasone treatment significantly reduced both spinal cord edema and clinical symptoms in affected animals.

    Conclusions:

    • The developed rat model effectively replicates spinal cord compression and associated pathologies.
    • Vasogenic edema and compromised vascular supply are key features of this compression model.
    • Dexamethasone demonstrates therapeutic potential in mitigating spinal cord edema and neurological deficits caused by compression.