Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An automatic device for single-breath CO diffusing capacity in dogs.

C M Derks, J Lisart, M Englert

    Pflugers Archiv : European Journal of Physiology
    |March 11, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Control of the legal practice of euthanasia in Belgium].

    Revue medicale de Bruxelles·2015
    Same author

    [Management of requests for euthanasia. Discussion of cases].

    Revue medicale de Bruxelles·2008
    Same author

    [Depenalized practice of euthanasia in Belgium: evolution from 2002 to 2005 and interpretation of the differences between the north and the south of the country].

    Revue medicale de Bruxelles·2007
    Same author

    [Two years of legal practice of euthanasia in Belgium: comparison with the Netherlands. First evaluation in a palliative care unit].

    Revue medicale de Bruxelles·2005
    Same author

    [Depenalized practice of euthanasia in Belgium].

    Revue medicale de Liege·2005
    Same author

    [Physician-assisted death. An essay of clarification].

    Revue medicale de Bruxelles·2004
    Same journal

    Expression of protein kinase A catalytic subunits in healthy and diseased mouse kidneys.

    Pflugers Archiv : European journal of physiology·2026
    Same journal

    Localization of O₂‑sensing ADO‑RGS pathway components in mouse and human kidneys under normoxia, hypoxia and renal fibrosis.

    Pflugers Archiv : European journal of physiology·2026
    Same journal

    Cholesterol-depleting dextrin depolarizes sarcolemma: the contribution of sodium / calcium channels and membrane integrity.

    Pflugers Archiv : European journal of physiology·2026
    Same journal

    Inhibition of (interstitial) P2Y<sub>6</sub> receptors attenuates fibrosis progression.

    Pflugers Archiv : European journal of physiology·2026
    Same journal

    Renal NHE3 is required to limit hypokalemia and metabolic acidosis during dietary potassium deficiency.

    Pflugers Archiv : European journal of physiology·2026
    Same journal

    Xenin-25 improves indomethacin-induced acute gastric injury in rats.

    Pflugers Archiv : European journal of physiology·2026
    See all related articles

    A new, simple system measures single-breath carbon monoxide diffusing capacity (DLCO) in dogs. This method provides reproducible results within the normal range, aiding canine respiratory research.

    Area of Science:

    • Veterinary Medicine
    • Pulmonary Physiology
    • Respiratory System Mechanics

    Background:

    • Accurate measurement of lung function is crucial in veterinary research.
    • Assessing diffusing capacity, specifically carbon monoxide diffusing capacity (DLCO), provides insights into gas exchange efficiency.
    • Existing methods for DLCO measurement in animals can be complex or lack reproducibility.

    Purpose of the Study:

    • To develop and describe a simple, pneumatically operated system for measuring single-breath carbon monoxide diffusing capacity (DLCO) in anesthetized dogs.
    • To evaluate the performance and reproducibility of this novel DLCO measurement system.

    Main Methods:

    • A novel, pneumatically controlled system was designed for single-breath DLCO measurements.
    • The system utilizes cams integrated with syringe pistons to automate valve control, dead space flushing, air injection, and sample collection.

    Related Experiment Videos

  • Measurements were performed on anesthetized dogs, with results adjusted for body weight.

    • Main Results:

    • The developed system allows for simple operation and accurate DLCO measurements in dogs.
    • Results obtained were comparable to the upper range of normal values reported in previous canine studies.
    • The method demonstrated good reproducibility, indicating its reliability for repeated measurements.

    Conclusions:

    • This pneumatically operated system offers a straightforward and reliable method for assessing DLCO in dogs.
    • The system's simplicity and good reproducibility make it a valuable tool for canine respiratory research and physiological studies.
    • The findings support the utility of this method for advancing our understanding of gas exchange in canine models.