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Related Experiment Videos

Does androgen influence prolactin secretion?

J M Nolin, G T Campbell, D D Nansel

    Endocrine Research Communications
    |January 1, 1977
    PubMed
    Summary

    Dihydrotestosterone (DHT) does not stimulate prolactin (PRL) secretion in rats, unlike testosterone. This suggests testosterone

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    Endocrine·1997

    Area of Science:

    • Endocrinology
    • Reproductive biology
    • Hormone research

    Background:

    • Testosterone and estrogen are known to influence prolactin (PRL) secretion.
    • Generalizations suggest androgens and estrogens stimulate PRL secretion.
    • The specific mechanisms and differing effects of androgens require further investigation.

    Purpose of the Study:

    • To investigate the effects of dihydrotestosterone (DHT), a pure androgen, on prolactin (PRL) secretion in rats.
    • To differentiate the PRL-secretory actions of DHT from those of testosterone.
    • To elucidate the role of androgenic versus estrogenic metabolites in mediating hormone secretion.

    Main Methods:

    • Administration of DHT to intact and castrated male and female rats.
    • Monitoring of prolactin (PRL) and luteinizing hormone (LH) levels.
    • Assessment of ventral prostate growth in male rats.

    Main Results:

    • DHT failed to stimulate PRL secretion in all tested rat groups.
    • DHT inhibited LH release and stimulated prostate growth in males.
    • DHT suppressed PRL release in intact females, contrasting with other groups.
    • Testosterone's PRL-stimulatory effects appear linked to its estrogenic metabolites, not its androgenic action.

    Conclusions:

    • DHT lacks the PRL-stimulatory capacity attributed to testosterone.
    • Testosterone's influence on PRL secretion is mediated by its conversion to estrogens.
    • These findings challenge broad generalizations about androgenic effects on PRL secretion.

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