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Related Experiment Videos

Mortality in diabetic autonomic neuropathy.

D J Ewing, I W Campbell, B F Clarke

    Lancet (London, England)
    |March 20, 1976
    PubMed
    Summary

    Diabetic autonomic neuropathy prognosis is guided by simple autonomic function tests. Abnormal tests in diabetic patients indicate a high mortality risk, with causes including renal failure and sudden death.

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    Area of Science:

    • Endocrinology
    • Neurology
    • Cardiology

    Background:

    • Diabetic autonomic neuropathy presents with diverse symptoms.
    • Autonomic dysfunction significantly impacts diabetic patient outcomes.
    • Prognostic indicators for diabetic autonomic neuropathy are crucial.

    Purpose of the Study:

    • To assess the prognostic value of autonomic function tests in diabetics.
    • To correlate autonomic function test results with patient mortality and morbidity.

    Main Methods:

    • Prospective follow-up of 37 diabetic patients with suspected autonomic neuropathy over 33 months.
    • Utilized Valsalva and handgrip tests for autonomic function assessment.
    • Repeated autonomic function tests in survivors after 18-24 months.

    Main Results:

    • Ten out of 20 patients (50%) with initially abnormal autonomic tests died.
    • Causes of death included renal failure, cerebrovascular accident, hypoglycemic coma, and sudden death.
    • Survivors with initially abnormal tests showed worsening neuropathy; some with normal tests improved.

    Conclusions:

    • Simple autonomic function tests are valuable prognostic tools in diabetic autonomic neuropathy.
    • Abnormal autonomic function tests are strongly associated with increased mortality in diabetics.
    • Monitoring autonomic function can guide clinical management and predict outcomes.

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