Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cells regulate their proliferation through alterations in transition probability.

R Shields, J A Smith

    Journal of Cellular Physiology
    |June 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Free radical generation in hydroperoxide-treated erythrocytes monitored continuously by luminol-amplified chemiluminescence.

    Biochemistry international·1992
    Same author

    The presence of high-titer HLA antibodies in cardiac transplant recipients.

    Transplantation·1992
    Same author

    Role of guinea pig and rabbit hepatic aldehyde oxidase in oxidative in vitro metabolism of cinchona antimalarials.

    Drug metabolism and disposition: the biological fate of chemicals·1992
    Same author

    Comparison of intravenous contrast agents for CT studies in children.

    Acta radiologica (Stockholm, Sweden : 1987)·1992
    Same author

    kappa-Opioid inhibition of [3H]dopamine release from rat ventral mesencephalic dissociated cell cultures.

    Molecular pharmacology·1992
    Same author

    Mechanical circulatory support: a necessary adjunct to a cardiac transplantation service.

    Transplantation proceedings·1992
    Same journal

    Mt1-Ca<sup>2+</sup>-Mitochondrial Metabolic Axis Maintains Temporomandibular Joint Condylar Cartilage Homeostasis Under Low Oxygen and Hypoxic Condition.

    Journal of cellular physiology·2026
    Same journal

    Correction to "IRE1α/NOX4 Signaling Pathway Mediates Ros-Dependent Activation of Hepatic Stellate Cells in NaAsO<sub>2</sub>-Induced Liver Fibrosis".

    Journal of cellular physiology·2026
    Same journal

    Lipocalin-2 Restores Mitochondrial and Antioxidant Adaptation in a Strain-Specific Manner During LPS Induced Sepsis.

    Journal of cellular physiology·2026
    Same journal

    Dysregulation of Non-Muscle Myosin IIA Assembly and Phosphorylation in S100A4 Null Mouse Lens.

    Journal of cellular physiology·2026
    Same journal

    Corrigendum to "A Probiotic Combination of Limosilactobacillus reuteri and Clostridium butyricum Ameliorates 5-Fluorouracil-Induced Intestinal Mucositis in Rats by Strengthening Barrier Integrity and Modulating Immuno-Microbial Homeostasis".

    Journal of cellular physiology·2026
    Same journal

    Sexually Dimorphic Regulation of MiR-29a/c-3p in Human Endothelial Cells: Cell Functions and Transcriptome.

    Journal of cellular physiology·2026
    See all related articles

    The transition probability model accurately explains cell cycle progression and proliferation rates across various cell types. This model suggests that the "transition probability" (P) parameter biochemically regulates cell growth in vitro and in vivo.

    Area of Science:

    • Cell Biology
    • Biophysics

    Background:

    • Understanding cell cycle regulation is crucial for comprehending cell proliferation.
    • Previous models of the cell cycle have limitations in explaining diverse proliferation rates.

    Purpose of the Study:

    • To investigate the cell cycle kinetics of 3T3, 3T6, and SV3T3 cells under varying growth conditions.
    • To evaluate the applicability of the transition probability model to different cell proliferation rates.

    Main Methods:

    • Time-lapse cinephotography was employed to observe and record cell division.
    • Analysis of intermitotic time distributions was performed for different cell lines and conditions.

    Main Results:

    • The frequency distributions of intermitotic times were well-explained by the transition probability model.

    Related Experiment Videos

  • Quiescent cells exhibited very low transition probability values.
  • No distinct "out of cycle" or G0 compartment was detected.

    • Conclusions:

    • The rate of cell proliferation is determined by the transition probability (P).
    • The transition probability (P) is the biochemical determinant of cell growth regulation.
    • The transition probability model provides a unified framework for understanding cell cycle kinetics and proliferation.