Related Experiment Videos
Cerebral mucormycosis following experimental inoculation with Mortierella wolfii
Mycopathologia
|April 29, 1977
Abstract:
A strain of Mortierella wolfii isolated from a case of bovine mycotic abortion in the United Kingdom did not produce disease in mice when inoculated by the intraperitoneal, intramuscular, intravenous or subcutaneous routes. When injected by the intracerebral route, it induced a chronic granulomatous infection of the brain resulting in hydrocephalus and eventually death.
Insights
Mortierella wolfii, a fungus causing bovine abortion, did not infect mice through common inoculation routes. However, intracerebral injection led to fatal brain infections, causing hydrocephalus in the animal model.
Area of Science:
- Veterinary Mycology
- Pathogen Research
Background:
- Mortierella wolfii is a fungal agent known to cause mycotic abortion in cattle.
- Understanding the pathogenicity of M. wolfii in animal models is crucial for disease control.
Purpose of the Study:
- To evaluate the pathogenicity of a UK-isolated Mortierella wolfii strain in a murine model.
- To determine the effects of different inoculation routes on disease development.
Main Methods:
- A Mortierella wolfii strain from bovine mycotic abortion was used.
- Mice were inoculated via intraperitoneal, intramuscular, intravenous, subcutaneous, and intracerebral routes.
Main Results:
- No disease was observed in mice following non-neural inoculation routes.
- Intracerebral inoculation resulted in chronic granulomatous brain infection.
- This infection led to hydrocephalus and mortality in the inoculated mice.
Conclusions:
- The route of inoculation significantly influences the pathogenicity of Mortierella wolfii in mice.
- The central nervous system appears to be a potential target for M. wolfii pathogenesis, leading to severe outcomes.