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Haemorrhagic diathesis in children associated with vitamin K deficiency
Journal of Clinical Pathology
|May 1, 1967
Insights
Infants experienced severe bleeding disorders due to vitamin K deficiency, leading to abnormal clotting. Vitamin K treatment successfully corrected this coagulation abnormality in affected infants.
Area of Science:
- Pediatrics
- Hematology
- Nutritional Science
Background:
- Infantile hemorrhagic diathesis presents with constitutional symptoms like fever, diarrhea, vomiting, anorexia, and pallor.
- A severe coagulation abnormality was observed in affected infants.
Purpose of the Study:
- To describe a hemorrhagic diathesis in infants.
- To investigate the underlying coagulation abnormality and its potential causes.
Main Methods:
- Clinical observation of infants presenting with hemorrhagic diathesis and constitutional symptoms.
- Assessment of coagulation status and vitamin-K-dependent factors.
- Evaluation of the response to vitamin K administration.
Main Results:
- Infants exhibited a severe coagulation abnormality attributed to a deficiency in vitamin-K-dependent factors.
- Administration of vitamin K effectively corrected the observed coagulation defect.
- The etiology of this condition remains undetermined, though potential causes were discussed.
Conclusions:
- Vitamin K deficiency is the cause of a specific hemorrhagic diathesis in infants.
- Vitamin K administration is an effective treatment for this condition.
- Further research is needed to elucidate the etiology of this infantile hemorrhagic diathesis.
Abstract:
A haemorrhagic diathesis is described in infants; this is preceded and accompanied by constitutional symptoms such as fever, diarrhoea, vomiting, anorexia, and pallor. These children had a severe coagulation abnormality, due to deficiency of vitamin-K-dependent coagulation factors, and it was corrected by administration of vitamin K. No conclusion could be drawn as to the aetiology of this condition but some possible causes are discussed.