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Desmosomal abnormalities in the liver of methotrexate-treated psoriatics

E Horvath, K Kovacs, R C Ross

Experientia

|September 15, 1977

Abstract:

Electron microscopy of the liver of methotrexate-treated psoriatic patients revealed junctional abnormalities consisting of detachment of desmosomal plaques between hepatocytes. Mitochondria anchoring desmosomal microfilaments were frequently noted.

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