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Related Experiment Video

Updated: Jul 25, 2026

Isolation of Intact Eyeball to Obtain Integral Ocular Surface Tissue for Histological Examination and Immunohistochemistry

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The orbicularis oculi reflex: pathologic studies in childhood.

S A Clay, J C Ramseyer

|September 1, 1977

Summary

The orbicularis oculi reflex is a valuable tool for diagnosing brain stem diseases in children. This reflex test showed abnormalities in most children with brain stem gliomas, similar to adult findings.

Area of Science:

Pediatric Neurology
Neuroscience
Ophthalmology

Background:

Brain stem gliomas and posterior fossa pathologies can significantly impact neurological function in children.
The orbicularis oculi reflex is a well-established neurological examination component.

Purpose of the Study:

To evaluate the utility of the orbicularis oculi reflex in diagnosing brain stem diseases in pediatric patients.
To compare reflex alterations in children with brain stem gliomas to those with other posterior fossa pathologies and to normal childhood values.

Main Methods:

Studied the orbicularis oculi reflex in 12 children with intrinsic brain stem gliomas.
Included six children with other posterior fossa pathology for comparison.
Compared results against established childhood normal values.

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Main Results:

Seventy-eight percent of the studied children exhibited a pathologic alteration of the orbicularis oculi reflex.
The observed alterations were comparable to those previously reported in adult patients.
This suggests a consistent pattern of reflex dysfunction across age groups for similar pathologies.

Conclusions:

The orbicularis oculi reflex test is a simple and risk-free procedure for evaluating brain stem disease in children.
Abnormalities in this reflex are indicative of underlying brain stem pathology in pediatric populations.
This diagnostic method offers valuable insights into neurological function in children with posterior fossa conditions.