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Related Experiment Videos

Primary empty sella syndrome with elevated serum prolactin.

J R Bryner, R B Greenblatt

    Obstetrics and Gynecology
    |September 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

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    This case study discusses a young woman with amenorrhea-galactorrhea syndrome and elevated prolactin (PRL) levels. It questions the safety of ovulation induction given her empty sella and unexplained pituitary enlargement.

    Area of Science:

    • Endocrinology
    • Reproductive Medicine
    • Neuroendocrinology

    Background:

    • Presents a case of a young adult female with a history of amenorrhea-galactorrhea syndrome.
    • Notes known pituitary enlargement since 1969.
    • Highlights elevated serum prolactin (PRL) levels, suggestive of a microadenoma.

    Observation:

    • The patient exhibited an empty sella, a condition where the pituitary gland appears shrunken within the sella turcica.
    • Despite elevated PRL, a definitive pituitary adenoma could not be confirmed through diagnostic studies.
    • The patient expressed a desire for pregnancy.

    Findings:

    • The diagnostic workup revealed elevated PRL levels within the microadenoma range.
    • An empty sella was identified.

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  • The presence of a pituitary adenoma remained unconfirmed.

    • Implications:

    • Raises a clinical question regarding the management of infertility in women with elevated PRL and empty sella.
    • Considers the potential risks and benefits of attempting ovulation induction in this specific patient profile.
    • Underscores the diagnostic challenges in differentiating causes of hyperprolactinemia and empty sella.