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Plasma cortisol in glaucoma.

S Ray, K S Mehra, S Misra

    Annals of Ophthalmology
    |September 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Glaucoma patients exhibit higher plasma cortisol levels and more pronounced diurnal cortisol variations, which parallel intraocular tension changes. These findings suggest a link between cortisol dynamics and glaucoma development.

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    Area of Science:

    • Endocrinology
    • Ophthalmology
    • Clinical Physiology

    Background:

    • Glaucoma is a leading cause of irreversible blindness.
    • Intraocular tension is a key risk factor for glaucoma.
    • Cortisol, a stress hormone, has known systemic effects.

    Purpose of the Study:

    • To investigate diurnal variations in plasma cortisol levels.
    • To compare plasma cortisol and intraocular tension in normal and glaucomatous individuals.
    • To explore the relationship between cortisol diurnal rhythm and intraocular tension in glaucoma.

    Main Methods:

    • Diurnal plasma cortisol levels and intraocular tension were measured.
    • Measurements were taken at 8 AM and 8 PM.
    • 40 normal and 40 glaucomatous patients participated.

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    Main Results:

    • Plasma cortisol levels were significantly higher in glaucomatous patients.
    • Diurnal cortisol variation paralleled diurnal intraocular tension variation in both groups.
    • Glaucomatous patients showed more marked diurnal cortisol fluctuations.

    Conclusions:

    • Elevated plasma cortisol and altered diurnal cortisol patterns are associated with glaucoma.
    • The parallel diurnal variation suggests a potential link between cortisol and intraocular tension regulation.
    • Further research is warranted to elucidate the role of cortisol in glaucoma pathophysiology.