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Related Experiment Videos

Oxygen consumption in the developing chick cornea.

E Masterson, H F Edelhauser

    Investigative Ophthalmology & Visual Science
    |November 1, 1977
    PubMed
    Summary

    Corneal oxygen consumption in embryonic chicks decreases with development. Hormonal treatments with thyroxine and thiouracil significantly alter this metabolic rate during key developmental stages.

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    Area of Science:

    • Developmental Biology
    • Physiology
    • Biochemistry

    Background:

    • The cornea's metabolic activity is crucial for its development and function.
    • Understanding oxygen consumption patterns provides insights into corneal physiology.

    Purpose of the Study:

    • To investigate the changes in embryonic chick corneal oxygen consumption (QO2) throughout development.
    • To evaluate the effects of thyroxine and thiouracil on corneal metabolic activity.

    Main Methods:

    • Embryonic chick corneas were assessed for oxygen consumption at various developmental stages.
    • Hormonal treatments included administration of thyroxine and thiouracil.
    • Oxygen consumption was measured as QO2 (per mg dry weight) and per corneal pair.

    Main Results:

    • Untreated corneas showed a decrease in QO2 from 3.60 at stage 38 to 1.58 post-hatching.
    • Oxygen consumption per corneal pair increased from 3.20 at stage 38 to 6.20 post-hatching, with a plateau between stages 40-45.
    • Thiouracil reduced corneal O2 consumption, while thyroxine increased it at specific developmental stages.

    Conclusions:

    • Corneal oxygen consumption exhibits significant developmental changes in embryonic chicks.
    • Thyroxine and thiouracil modulate corneal metabolic rates, suggesting hormonal influence on corneal development and function.

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