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[Computer assisted heart and circulation analysis in experimental septic shock (author's transl)]
Klinische Padiatrie
|September 1, 1977
Summary
Developing a septic shock model aids in understanding its pathogenesis and identifying lethal organs. The hyperkinetic syndrome may be a key factor, with data analyzed by computer.
Area of Science:
- Physiology
- Pathology
- Computational Biology
Context:
- Septic shock pathogenesis requires a robust clinical model.
- Identifying organ-specific lethality is crucial for treatment.
- The hyperkinetic syndrome's role in shock is under-explored.
Purpose:
- To develop a computational model simulating septic shock.
- To investigate the contribution of the hyperkinetic syndrome to septic shock.
- To correlate model outputs with clinical manifestations and identify lethal organs.
Summary:
- A computational model for septic shock was developed using experimental data.
- The model incorporates the hyperkinetic syndrome as a potential key factor.
- Experimental apparatus and Fortran program structure are detailed for reproducibility.
Impact:
- Provides a framework for further septic shock research.
- Facilitates identification of critical determinants of organ failure in sepsis.
- Enables in silico experimentation to test therapeutic strategies.