[Ifosfamide in the treatment of nephrotic syndrome (author's transl)]

Ifosfamide, an alkylating agent was used successfully in the treatment of children with steroid sensitive nephrotic syndrome with minimal changes. Remissions have persisted for about 6 years. Toxicity was very minor, and the regimen constitutes a useful advance in management of these patients. Ifosfamide had no significant effect on children with steroid resistence nephrotic syndrome or other morphological changes. Because the potential gonadal dysfunction Ifosfamide should be given only in patients with steroid toxicity or frequent relapsers.