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Updated: May 4, 2026

Visualization of DNA Replication in the Vertebrate Model System DT40 using the DNA Fiber Technique
Published on: October 27, 2011
Effect of n-butyrate on DNA synthesis in chick fibroblasts and HeLa cells
Abstract:
n-Butyrate in low concentrations stops reversibly the proliferation of chick embryonic fibroblasts and of HeLa cells, shutting off DNA synthesis. Extensive acetylation of histones is seen at the same time as inhibition of DNA synthesis. Nuclei from n-butyrate-treated HeLa cells remain inactive in control cytosol; control nuclei are strongly inhibited by cytosol from treated cells.
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