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Related Experiment Videos

Decrease of prolactin by methysergide in amenorrheic hyperprolactinemic women.

R D'Agata, S Ando, L Iachello

    The Journal of Clinical Endocrinology and Metabolism
    |November 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

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    Methysergide (MES) significantly lowered prolactin (PRL) blood levels in women with hyperprolactinemic amenorrhea. This suggests serotonin plays a role in regulating PRL release, with MES potentially reducing PRL by decreasing serotonin activity.

    Area of Science:

    • Endocrinology
    • Neuropharmacology
    • Reproductive Medicine

    Background:

    • Hyperprolactinemia is associated with amenorrhea and infertility.
    • Serotonin is implicated in the regulation of prolactin (PRL) secretion.
    • Methysergide (MES) is a known serotoninergic antagonist.

    Purpose of the Study:

    • To investigate the effect of methysergide (MES) on blood prolactin (PRL) levels in hyperprolactinemic women.
    • To explore the potential role of serotonin in PRL regulation.

    Main Methods:

    • Five women with hyperprolactinemic amenorrhea were treated with methysergide (MES).
    • The daily dosage administered was 11.2 mg for five consecutive days.
    • Blood samples were analyzed to measure PRL levels before and during treatment.

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    Main Results:

    • Methysergide (MES) administration resulted in a significant decrease in PRL blood levels across all subjects (p < 0.01).
    • The observed reduction in PRL levels was consistent among all participants.

    Conclusions:

    • Methysergide (MES) effectively lowers prolactin (PRL) levels in hyperprolactinemic amenorrheic women.
    • These findings support the hypothesis that serotonin influences PRL release.
    • The antiserotoninergic effect of MES may contribute to the reduction in PRL by decreasing central serotonin tone.