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[BCG-osteomyelitis and BCG-arthritis after vaccination with BCG (author's transl)]
Medizinische Klinik
|October 28, 1977
Insights
BCG osteomyelitis, a rare complication of newborn vaccination, can manifest years later with subtle bone lesions. Early diagnosis and intensive treatment are crucial to prevent growth disturbances and joint mobility issues.
Area of Science:
- Pediatric Infectious Diseases
- Orthopedic Surgery
- Vaccinology
Background:
- Bacille Calmette-Guérin (BCG) vaccination is standard for newborns.
- BCG osteomyelitis is a rare but serious adverse event.
- Delayed diagnosis can lead to significant complications.
Abstract:
After vaccination with BCG (type Goeteborg) in the newborn period two children developed a BCG-osteomyelitis 12 and 19 months respectively later. The symptoms were only small. X-ray showed bone lesions in the distal metaphysis of the femur. The bacteriological examination demonstrated BCG-etiology. Disturbances of growth or of joint motility are seldom; they are possible, if the bone lesions are severe and if the diagnosis is late. In these cases the treatment must be intensive.