[Reactivity of castrated female rats to estrone in alloxan diabetes]

After the administration of alloxan (in 23 days) to adult female rats the mass of the ovaries, the uterus, and the vagina altered, but the height of the uterine endometrium and the thickness of the vaginal epithelial layer decreased. When estron was administered to castrated rats with alloxan diabetes the mass of the uterus and the vagina and the height of the uterine endometrium, and of the epithelial layer of the vagina increased to the same degree as in rats with the intact pancreas; reactivity of diabetic rats to estrogen approached the sensitivity of animals with normal pancreatic functions.