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[Immunity after newcastle disease in man (author's transl)]
Wiener Klinische Wochenschrift
|November 25, 1977
Summary
Newcastle disease in humans, diagnosed via positive haemagglutination inhibition test (HIT), showed no ophthalmological findings upon re-examination. Antibody levels decreased significantly over time, with only one of five patients retaining a positive HIT result.
Area of Science:
- Ophthalmology
- Virology
- Immunology
Background:
- Newcastle disease, a viral avian pathogen, can occasionally infect humans.
- Human infections are typically associated with poultry handling.
- Previous studies documented ophthalmological manifestations in rare human cases.
Purpose of the Study:
- To re-evaluate long-term ophthalmological outcomes in patients previously diagnosed with human Newcastle disease.
- To assess the persistence of antibodies and serological markers in these patients over an extended period.
Main Methods:
- Retrospective case review of five patients diagnosed with Newcastle disease in 1970.
- Ophthalmological examinations conducted during recent follow-up.
- Serological testing, specifically the haemagglutination inhibition test (HIT), to detect antibodies.
Main Results:
- All five patients exhibited negative ophthalmological findings during the recent re-examination.
- The haemagglutination inhibition test (HIT) remained positive (titer 1:8) in only one patient.
- Antibodies were not detected in the remaining four patients, indicating serological clearance.
Conclusions:
- Human Newcastle disease does not appear to cause persistent ophthalmological sequelae.
- Serological markers, such as positive HIT, may wane over extended periods following infection.
- Long-term follow-up suggests a favorable prognosis regarding ocular health in human Newcastle disease survivors.