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Related Experiment Videos

Human dander in house dust allergy.

W D Brighton, M D Topping

    Clinical Allergy
    |November 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Human dander may play a role in house dust allergy. Studies found IgE antibodies to human skin extract in allergic patients, suggesting cross-reactivity with common allergens like dust mites and cat fur.

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    Area of Science:

    • Allergen immunotherapy
    • Immunology
    • Environmental health

    Background:

    • House dust allergy is a prevalent condition.
    • The specific allergens responsible for house dust allergy are not fully understood.
    • Human dander has been proposed as a potential allergen.

    Purpose of the Study:

    • To investigate the role of human dander in house dust allergy.
    • To determine if IgE antibodies to human dander are present in patients with house dust allergy.
    • To explore potential cross-reactivity between human dander and other common allergens.

    Main Methods:

    • Collection of naturally shed, mite-free human skin squames.
    • Preparation of a human dander extract.
    • Use of the Radioallergosorbent assay (RAST) to detect IgE titres.

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  • RAST inhibition studies to assess cross-reactivity.

    • Main Results:

    • IgE titres to human skin extract were detected in sera from patients with house dust allergy.
    • These sera also showed high IgE titres to house dust, Dermatophagoides pteronyssinus, or cat fur.
    • RAST inhibition studies indicated cross-reactivity between human skin extract and extracts of D. pteronyssinus and cat fur.

    Conclusions:

    • Human dander may be an allergen contributing to house dust allergy.
    • Cross-reactivity exists between human dander, dust mite allergens, and cat fur allergens.
    • Further research is warranted to elucidate the precise role of human dander in allergic diseases.