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Related Experiment Videos

Concurrent intracranial self-stimulation and amphetamine self-administration in rats.

R A Wise, R A Yokel, P A Hansson

    Pharmacology, Biochemistry, and Behavior
    |November 1, 1977
    PubMed
    Summary

    Rats increased lever pressing for both amphetamine and brain stimulation when offered together. Amphetamine

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    Area of Science:

    • Neuroscience
    • Behavioral Pharmacology
    • Psychopharmacology

    Background:

    • Concurrent access to multiple reinforcers is common in real-world scenarios.
    • Understanding how animals respond to combined drug and brain stimulation rewards is crucial for addiction research.

    Purpose of the Study:

    • To investigate the effects of concurrent access to intravenous amphetamine and brain stimulation on rat behavior.
    • To determine if amphetamine-induced behaviors interfere with lever pressing for brain stimulation.

    Main Methods:

    • Rats were trained to press levers for intravenous amphetamine and/or brain stimulation in a two-lever testing chamber.
    • Response rates for each reinforcer were compared under conditions of single and concurrent access.
    • Behavioral observations were conducted to assess amphetamine stereotypy.

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    Main Results:

    • Concurrent access to both reinforcers generally increased responding for each compared to single-reinforcer conditions.
    • Amphetamine-induced stereotyped behaviors were observed but did not impede rapid lever pressing for brain stimulation.
    • Rats demonstrated the ability to modulate their responding based on the availability of different reinforcers.

    Conclusions:

    • Rats can effectively manage concurrent operant responding for both drug and brain stimulation reinforcers.
    • Brain stimulation remains a potent reinforcer even in the presence of amphetamine, suggesting distinct neural pathways or motivational systems.
    • These findings contribute to understanding the complex interplay of reward systems in the brain and have implications for addiction models.