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Related Experiment Videos

Diurnal variation in urinary oxalate.

T B Hargreave, A Sali, C Mackay

    British Journal of Urology
    |January 1, 1977
    PubMed
    Summary

    Urinary oxalate levels increase during the day and decrease in the early morning. Dietary oxalate likely influences this diurnal variation, suggesting 24-hour urine collections may not accurately reflect peak oxalate excretion.

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    Area of Science:

    • Nephrology
    • Urology
    • Nutritional Science

    Background:

    • Urinary oxalate is a key factor in kidney stone formation.
    • Understanding diurnal variations in oxalate excretion is crucial for metabolic assessment.

    Purpose of the Study:

    • To investigate the diurnal pattern of urinary oxalate concentration and output.
    • To explore the relationship between dietary intake and diurnal oxalate excretion.

    Main Methods:

    • Collected urine samples from 10 catheterized males over a 24-hour period.
    • Measured urinary oxalate concentration and output at different times of the day.

    Main Results:

    • Observed a significant increase in urinary oxalate concentration and output during daytime and evening hours.
    • Noted a decrease in urinary oxalate levels during the early morning.
    • Hypothesized that dietary oxalate intake contributes to the observed daytime increase.

    Conclusions:

    • Urinary oxalate excretion exhibits a distinct diurnal rhythm, peaking during the day.
    • A standard 24-hour urine collection may underestimate the extent of diurnal oxalate excretion.
    • Further research into dietary oxalate's role in diurnal excretion patterns is warranted.

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