Related Experiment Video

Updated: Aug 16, 2026

An In Vitro Model of a Parallel-Plate Perfusion System to Study Bacterial Adherence to Graft Tissues
07:50

An In Vitro Model of a Parallel-Plate Perfusion System to Study Bacterial Adherence to Graft Tissues

Published on: January 7, 2019

Clindamycin in infective endocarditis

C E Cherubin, S R Nair

    JAMA
    |February 13, 1978
    PubMed

    Insights

    Intramuscular clindamycin effectively treated endocarditis in most patients when penicillin allergy or IV access was an issue. Testing for Staphylococcus aureus resistance to clindamycin is recommended for optimal treatment selection.

    Area of Science:

    • Infectious Diseases
    • Pharmacology
    • Cardiology

    Background:

    • Endocarditis poses significant treatment challenges, particularly for patients with penicillin allergies or limited intravenous access.
    • Alternative antibiotic administration routes and agents are crucial for managing complex endocarditis cases.

    Purpose of the Study:

    • To evaluate the efficacy and safety of intramuscular clindamycin for treating endocarditis in patients unsuitable for standard therapies.
    • To assess the development of antimicrobial resistance during clindamycin treatment.

    Main Methods:

    • Nine patients with endocarditis received intramuscular clindamycin.
    • Patient cohorts included those with staphylococcal endocarditis (n=5) and alpha-streptococcal endocarditis (n=4).
    • Clinical outcomes and development of resistance were monitored.

    Main Results:

    • Clindamycin demonstrated therapeutic success in the majority of patients.
    • One patient with Staphylococcus aureus endocarditis experienced treatment failure due to in vivo development of clindamycin resistance.
    • No other adverse events or treatment failures were reported.

    Conclusions:

    • Intramuscular clindamycin is a viable treatment option for selected endocarditis cases, especially when penicillin allergy or IV access is problematic.
    • Pre-treatment in vitro testing for clindamycin resistance in Staphylococcus aureus strains is advisable to ensure treatment efficacy.
    • Further research into antimicrobial resistance patterns is warranted for optimizing antibiotic selection in endocarditis.

    More Related Videos

    Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method12:03

    Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

    Published on: April 18, 2019

    In Vivo Mouse Model of Spinal Implant Infection08:03

    In Vivo Mouse Model of Spinal Implant Infection

    Published on: June 23, 2020

    Related Concept Videos

    Endocarditis I: Introduction01:25

    Endocarditis I: Introduction

    Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
    Endocarditis III: Medical Management01:18

    Endocarditis III: Medical Management

    Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
    Endocarditis IV: Nursing Management01:29

    Endocarditis IV: Nursing Management

    Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
    Myocarditis II: Clinical Features and Diagnostic Tests01:27

    Myocarditis II: Clinical Features and Diagnostic Tests

    Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
    Myocarditis III: Medical Management01:14

    Myocarditis III: Medical Management

    Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
    Streptococcal Pharyngitis01:27

    Streptococcal Pharyngitis

    Streptococcal pharyngitis, commonly known as “strep throat,” is an acute infection of the oropharyngeal tissues caused by the Gram‑positive Group A Streptococcus (Streptococcus pyogenes). Transmission occurs primarily through respiratory droplets expelled during coughing, sneezing, or talking.Mechanisms of Host Entry and Immune EvasionUpon entering the host, S. pyogenes adheres to the mucosal epithelial cells of the pharynx via surface proteins, notably lipoteichoic acid and the antiphagocytic...