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RELATIONSHIP BETWEEN THE Mason-Pfizer monkey virus and Hela virus: immunoelectron microscopy
Journal of the National Cancer Institute
|March 1, 1976
Summary
Mason-Pfizer monkey virus (MPMV) and HeLa virus share identical envelope antigens. This suggests a very close relationship, potentially even identity, between these two viruses based on their surface proteins.
Area of Science:
- Virology
- Immunology
- Cell Biology
Background:
- Mason-Pfizer monkey virus (MPMV) is a known simian retrovirus.
- HeLa virus is a contaminant observed in some HeLa cell lines.
- Morphological similarities exist between MPMV and HeLa virus.
Purpose of the Study:
- To compare the envelope antigens of MPMV and HeLa virus.
- To determine the antigenic relationship between MPMV and HeLa virus.
Main Methods:
- Indirect immunoferritin techniques were employed.
- Antisera against MPMV and HeLa virus were used.
- Cross-absorption and end-point dilution assays were performed.
Main Results:
- Cross-reacting antigenic specificities were detected on the surfaces of both MPMV and HeLa virus.
- Cross-absorption and end-point dilution indicated identical envelope antigens.
- MPMV and HeLa virus share common surface proteins.
Conclusions:
- MPMV and HeLa virus exhibit a close antigenic relationship.
- The envelope antigens suggest that MPMV and HeLa virus may be identical.