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Updated: Aug 2, 2026

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Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
Published on: October 25, 2013
Interaction of staphylococcal penicillinase and 6-[D(-)-alphaguanidino-phenylacetamido]-penicillanic acid
Applied Microbiology
|February 1, 1968
Abstract:
6[d(-)-alpha-Guanidinophenylacetamido]-penicillanic acid was shown to be significantly hydrolyzed by only one of six preparations of staphylococcal penicillinase. This penicillin analogue is a stronger penicillinase inactivator than are nafcillin and methicillin, which were not significantly hydrolyzed by the enzyme.
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