[Change in the cortical and medullary renal circulation in centrogenic forms of arterial hypertension]

It was shown on 36 nonanesthetized rats by polarography from H2 elimination and PO2 recording that cortical and medullary circulation in the kidneys undergoes continuous fluctuations. A definite relation of these fluctuations with circulatory changes in the cerebral limbicoreticular structures was noted. In electric stimulation of the reticular formation and the hypothalamus on the background of arterial hypertension the cortical circulation decreased by 88.5% while the medullary circulation increased by 82.8%. In hypertension of over 180--235 mm Hg, the blood flow both in the cortical and in the medullary substance ceased practically. Chronic disturbance in the blood supply to the brain led to arterial hypertension and short-lived (10--20 days) increase of the blood plasma renin activity to 417.8% and its subsequent normalization by the 65th day. At the same time, renal blood flow dropped progressively and the reaction of the renal vessels to hypercapnic load became less manifest, which testified to changes in their reactive-structural characteristics. Summarizing the results obtained and the data of other investigators, the author concludes that neurogenous disorders of renal blood flow hold one of the key positions in the formation of arterial hypertension of different etiology.