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Mitoses in normal and psoriatic epidermis.

L Rowe, W J Dixon, A Forsythe

    The British Journal of Dermatology
    |March 1, 1978
    PubMed
    Summary
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    Psoriatic skin shows a higher afternoon cell division rate than normal skin, suggesting a larger, more reactive G2 cell population in psoriasis patients. This may contribute to the disease

    Area of Science:

    • Dermatology
    • Cell Biology
    • Epidermal Kinetics

    Background:

    • Psoriasis is a chronic inflammatory skin condition.
    • Understanding epidermal cell proliferation is key to psoriasis research.

    Purpose of the Study:

    • To investigate diurnal variations in epidermal cell mitosis in psoriatic and normal skin.
    • To explore the potential role of a non-cycling G2 population in psoriasis pathogenesis.

    Main Methods:

    • Quantitative analysis of mitotic counts in uninvolved psoriatic epidermis versus normal epidermis.
    • Comparison of morning and afternoon mitotic indices.

    Main Results:

    • No significant difference in morning mitosis counts between psoriatic and normal skin.

    Related Experiment Videos

  • Afternoon mitosis counts were higher than morning counts in both groups.
  • Uninvolved psoriatic epidermis showed significantly higher afternoon mitosis than normal epidermis.

    • Conclusions:

    • Results support the existence of a non-cycling G2 population in human epidermis.
    • This G2 population appears larger and more reactive to diurnal stimuli in psoriatics.
    • A labile G2 population may be implicated in the pathogenesis and etiology of psoriasis.