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Related Experiment Videos

Developmentally regulated slime mold lectins and specific cell cohesion.

S H Barondes

    Birth Defects Original Article Series
    |January 1, 1978
    PubMed
    Summary

    Cell surface lectins and receptors mediate slime mold cell cohesion during differentiation. Blocking these interactions with specific molecules inhibits cell-to-cell binding, suggesting a key role in this process.

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    Area of Science:

    • Cell biology
    • Developmental biology
    • Biochemistry

    Background:

    • Slime molds differentiate from noncohesive to cohesive forms.
    • Cell surface molecules play roles in cell-cell interactions.

    Purpose of the Study:

    • To investigate the role of cell surface lectins and receptors in slime mold cell cohesion.

    Main Methods:

    • Observed the appearance of lectins and receptors during slime mold differentiation.
    • Used quantitative assays to measure cell cohesion in *P. pallidum*.
    • Tested the effect of specific sugars, glycoproteins, and antibody fragments on cell cohesion.

    Main Results:

    • Cell surface lectins and receptors were detected on differentiating slime mold cells.
    • Specific sugars, glycoproteins, and antibody fragments blocked *P. pallidum* cell cohesion.
    • These blocking agents interfere with lectin-receptor interactions.

    Conclusions:

    • Cell surface lectin-receptor interactions likely mediate slime mold cell cohesion.
    • This interaction is a significant factor in the transition to a cohesive cellular state.

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