Anaphylactic shock following the administration of clindamycin

A case of anaphylactic shock following the administration of clindamycin is reported. The antibody response was studied by the passive haemagglutination reaction and the presence of haemagglutinating antibodies to both clindamycin and lincomycin was detected. In the discussion, the authors try to account for the causes of development of the mentioned anaphylactic reaction after a single therapeutic dose. In this connection they mention a possible development of haemagglutinating antibodies after the administration of two doses to the patient in an experiment at a long-term interval.