[Adrenergic and adrenolytic effects on the female urethra]

The effect of phentolamine and pholedrin sulfate on the female urethra was studied for electronical measurement of the urethral pressure profile. In 9 healthy women the administered of phentolamine (0,15 mg/kg body weight) resulted in a significant reduction of the maximal urethral closure pressure, the functional length of the urethra and the total areas under pressure profile. Following the injection of pholedrin sulfate (0,3 mg/kg body weight) a marked increase of the maximal urethral closure pressure and the total area under pressure profile was observed. The functional urethral length remained unchanged. New concepts of medicamentous influence of the urethral closure pressure were discussed.