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Updated: Aug 13, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
Published on: April 2, 2012
Severe thrombocytopenia after generalized herpes simplex virus-2 (HSV-2) infection
Abstract:
Our patient, we believe, experienced a primary HSV-2 infection manifested by fever, malaise, and orogenital mucocutaneous lesions. With resolution of systemic manifestations, and at a time of theorized rise in HSV-2 antibody levels, he had thrombocytopenic purpura which persisted for several weeks. An immune disorder secondary to HSV-2 infection similar to that of postrubella infection is postulated. If this theory is correct, severe immune thrombocytopenic purpura is yet one more of the many observed complications of HSV infection.
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