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External detection of axoplasmic flow using radionuclides.

L Widén, T Greitz, J Micheloyannakis

    Neuroradiology
    |January 1, 1976
    PubMed
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    Researchers studied axoplasmic flow in cats using radionuclide scanning with 75Se-methionine. The isotope spread within the spinal cord and dorsal roots, indicating successful in vivo visualization of axoplasmic transport.

    Area of Science:

    • Neuroscience
    • Radiology
    • Cell Biology

    Background:

    • Axoplasmic flow is crucial for neuronal function and integrity.
    • In vivo methods for studying axoplasmic flow are limited.
    • Radionuclide scanning offers potential for non-invasive visualization.

    Purpose of the Study:

    • To investigate the feasibility of studying axoplasmic flow in vivo using radionuclide scanning.
    • To track the distribution and movement of an injected radioisotope within the feline nervous system.

    Main Methods:

    • Injection of 75Se-methionine into feline spinal ganglia (L6, L7, S1).
    • In vivo imaging using a gamma camera to record isotope distribution.
    • Ex vivo scanning of spinal cord, nerve roots, ganglia, and nerves.

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  • Microautoradiography using 3H-methionine.

    • Main Results:

    • Isotope distribution extended 1-2 cm cranially and caudally in the spinal cord within 4 hours.
    • Further movement of 1-2 cm was observed over the subsequent 2-5 days.
    • Intramedullary and dorsal root uptake confirmed; isotope also detected in ventral roots and spinal nerves.
    • Microautoradiography showed isotope uptake in dorsal root axons and the spinal cord's root entry zone.

    Conclusions:

    • Radionuclide scanning with 75Se-methionine can visualize axoplasmic flow in vivo.
    • The observed isotope spread is consistent with axoplasmic transport mechanisms.
    • This study provides a foundation for further in vivo investigations of axoplasmic flow.