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[Adverse effect of amniofetography on fetal thyroid function (author's transl)]
Annales D'Endocrinologie
|January 1, 1978
Summary
Amniofetography, used to diagnose fetal malformations, involves radiopaque dyes that temporarily impair fetal thyroid function. This study monitored thyroid-stimulating hormone and thyroxine levels in newborns after the procedure.
Area of Science:
- Medical imaging
- Endocrinology
- Fetal medicine
Background:
- Amniofetography is a diagnostic imaging technique for identifying fetal abnormalities.
- Iodinated radiopaque contrast agents are commonly used in amniofetography.
- The potential impact of these agents on fetal endocrine function requires investigation.
Purpose of the Study:
- To evaluate the effect of iodinated radiopaque dyes used in amniofetography on fetal thyroid function.
- To assess the transient impact on thyroid hormone levels in newborns exposed to amniofetography.
Main Methods:
- Serial measurements of serum thyrotropin (TSH) and thyroxine (T4) were performed.
- Seven newborn infants who underwent amniofetography were included in the study.
- Thyroid function was monitored post-procedure.
Main Results:
- Amniofetography using iodinated contrast agents was associated with a temporary disruption of fetal thyroid regulation.
- Post-procedure thyroid hormone levels indicated transient impairment.
Conclusions:
- Amniofetography can induce a transient impairment of fetal thyroid function.
- Clinicians should be aware of this potential side effect when interpreting neonatal thyroid assessments following the procedure.