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Induced amnestic confusional phenomena. Pathology and lateralization
The Journal of Nervous and Mental Disease
|September 1, 1978
Summary
Electrical stimulation of the hippocampus in epilepsy patients can cause memory loss similar to transient global amnesia. Pathology findings suggest these amnestic confusional phenomena involve unilateral brain mechanisms in the dominant hemisphere.
Area of Science:
- Neuroscience
- Neurology
- Pathology
Background:
- Amnestic confusional phenomena can be induced by hippocampal electrical stimulation in epilepsy patients.
- These phenomena share similarities with transient global amnesia (TGA).
Purpose of the Study:
- To present pathology findings supporting the link between hippocampal stimulation-induced amnesia and unilateral cerebral mechanisms.
- To further investigate the cerebral underpinnings of transient global amnesia-like states.
Main Methods:
- Analysis of pathology findings in epileptic patients undergoing hippocampal electrical stimulation.
- Correlation of clinical observations of amnestic confusional phenomena with pathological data.
Main Results:
- Pathology findings provide additional evidence for the proposed mechanism.
- The induced amnestic confusional phenomena are linked to unilateral cerebral mechanisms.
Conclusions:
- Hippocampal electrical stimulation in epilepsy can elicit TGA-like states.
- These states are associated with unilateral (dominant hemisphere) cerebral mechanisms, supported by pathology.