[Effect of antibulins on the distribution of fibrillar elements in mouse embryonal fibroblasts]

Effects of colcemid, colchicine and vinblastine on distribution of fibrillar elements (microtubules, microfilaments and 100 A filaments) in mouse embryo fibroblasts were studied by the transmission electron microscopy and by additional treatment of cells with cytochalasin B. All the fibrillar components under routine conditions were seen to form a system of elements with a radial distribution. After antitubulin treatment, the radial system was seen tranformed into a circular one, which consisted mainly of microfilament bundles apparently connecting cell peripheral attachment sites with each other.