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The use of informatics and automation to remove bottlenecks in drug discovery.

Dual inhibition of human type 4 phosphodiesterase isostates by (R, R)-(+/-)-methyl 3-acetyl-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-3- methyl-1-pyrrolidinecarboxylate.

Human recombinant phosphodiesterase 4B2B binds (R)-rolipram at a single site with two affinities.

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