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Miniature stimulator for chronic animals.

D M Smith

    Pflugers Archiv : European Journal of Physiology
    |August 25, 1978
    PubMed
    Summary
    This summary is machine-generated.

    A novel, lightweight pulse train generator is ideal for nerve stimulation experiments. This portable stimulator, suitable for chronic sciatic nerve stimulation in cats, offers variable parameters and long battery life.

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    Area of Science:

    • Biomedical Engineering
    • Neuroscience
    • Animal Models

    Background:

    • Nerve stimulation experiments require precise and adaptable electrical stimulation devices.
    • Existing stimulators may lack portability, long-term operation capabilities, or variable parameters necessary for chronic studies.

    Purpose of the Study:

    • To describe a new, small, and lightweight pulse train generator for nerve stimulation.
    • To present the device's electrical specifications and schematics.
    • To evaluate the effects of chronic sciatic nerve stimulation on muscle contraction time in cats.

    Main Methods:

    • Development of a continuously variable pulse train generator.
    • Chronic stimulation of the cat sciatic nerve for six weeks.
    • Measurement of changes in hind leg muscle contraction time.

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    Main Results:

    • The developed stimulator is small, lightweight, and battery-powered for over six weeks of operation.
    • Continuous variability in train and pulse frequency and duration is achieved.
    • Significant changes in cat hind leg muscle contraction time were observed after chronic sciatic nerve stimulation.

    Conclusions:

    • The described pulse train generator is a viable tool for chronic nerve stimulation studies in small animal models.
    • The device's portability and extended battery life facilitate long-term in-vivo experiments.
    • Chronic sciatic nerve stimulation impacts neuromuscular properties, as evidenced by altered muscle contraction times.