Benign and malignant proliferative response. Dermal infiltration, origin and importance.

Area of Science:

• Dermatology
• Immunology
• Pathology

Background:

• Lymphoreticular infiltration (LRI) is the most frequent dermal infiltration type.
• LRI comprises a dermal skeleton and infiltrating cells.
• The dermal skeleton includes post-capillary venules and activated fibroblasts.

Purpose of the Study:

• To define the components and characteristics of lymphoreticular infiltration (LRI).
• To explore the role of LRI in allergic reactions and lymphoma development.

Main Methods:

• Histological examination of dermal infiltrates.
• Identification of cellular components and their interactions within the dermis.

Main Results:

• Activated fibroblasts form the dermal skeleton of LRI.
• Monocytes and lymphocytes are primary infiltrating cells, with variations in leukocytes and plasma cells.
• Abnormal globulin production can occur with B-lymphocyte and plasma cell involvement.
• LRI is implicated in allergic reactions and neoplastic lymphocyte proliferation, leading to lymphomas.

Conclusions:

• Activated fibroblasts are the primary reticulum cells in the dermis.
• LRI is a key process in allergic responses and the pathogenesis of lymphomas.
• The degree of lymphocyte dedifferentiation influences lymphoma variety.