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Related Experiment Videos

Pharmacokinetics of pancreatic polypeptide in man.

T E Adrian, G R Greenberg, H S Besterman

    Gut
    |October 1, 1978
    PubMed
    Summary

    This study determined the pharmacokinetics of bovine pancreatic polypeptide (PP) in humans. Infusions revealed dose-dependent plasma levels and provided key data on PP metabolism and distribution in healthy subjects.

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    Area of Science:

    • Endocrinology
    • Pharmacology
    • Gastroenterology

    Background:

    • Pancreatic polypeptide (PP) is a hormone secreted by endocrine cells in the pancreas.
    • Its physiological roles in humans are not fully understood.
    • Understanding PP pharmacokinetics is crucial for potential therapeutic applications.

    Purpose of the Study:

    • To characterize the pharmacokinetic profile of pure bovine pancreatic polypeptide (PP) in healthy human subjects.
    • To determine key parameters such as half-life, metabolic clearance, and volume of distribution.
    • To establish baseline data for future research on PP's biological effects and therapeutic potential.

    Main Methods:

    • Intravenous infusion of pure bovine pancreatic polypeptide (PP) at escalating doses (1, 3, and 5 pmol/kg/min) over 60 minutes in 23 healthy volunteers.
    • Plasma PP levels were quantified using radioimmunoassay.
    • Pharmacokinetic parameters were calculated after cessation of the infusion.

    Main Results:

    • Achieved mean plasma PP levels of 203 +/- 34, 575 +/- 73, and 930 +/- 48 pmol/l at the respective infusion rates.
    • Determined a mean disappearance half-time of 6.9 +/- 0.3 minutes.
    • Calculated a metabolic clearance rate of 5.1 +/- 0.2 ml/kg/min and an apparent volume of distribution of 51 +/- 3 ml/kg.

    Conclusions:

    • This study provides the first comprehensive pharmacokinetic data for pancreatic polypeptide (PP) in humans.
    • The results offer essential insights into PP's absorption, distribution, metabolism, and excretion.
    • These findings lay the groundwork for further investigation into PP's physiological functions and clinical relevance.

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