[Cellular response in the mouse to two antigenic extracts from "Vibrio cholerae" (author's transl)]

At the cellular level the primary response in Balb/c mice to an antigen prepared from a strain of Vibrio cholerae Ogawa was studied by a localized vibriolytic plaque procedures which permits the enumeration of immunocytes. The antibody response to a single injection with identical doses of antigen was comparatively studied by both intraperitoneal and subcutaneous immunization. The highest titre was noted two weeks after the intraperitoneal and three days after the subcutaneous injection. Inhibition experiments were performed to obtain an estimate of the average of avidity of the bactericidal antibodies against the different antigens extracted from the vibrio. A correlation between the avidity and the protective properties was noted. The antigen which had a better immunogenetic effect showed the better binding.