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Related Experiment Videos

[Clinical aspects of massive transfusions].

K Eyrich, A Braun-Heine, P Sefrin

    Infusionstherapie Und Klinische Ernahrung
    |December 1, 1978
    PubMed
    Summary

    Massive transfusion in surgical patients often leads to death, primarily from hemorrhagic shock and complications like clotting issues. Optimal therapy involves continuous blood volume, factor replacement, and careful monitoring.

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    Area of Science:

    • Medicine
    • Surgery
    • Critical Care

    Background:

    • Massive transfusion (≥51 units/6 hours) is a critical intervention in severe surgical bleeding.
    • Investigated clinical outcomes in 30 patients undergoing surgery or urological procedures requiring massive transfusion.

    Observation:

    • Primary bleeding sources included large tumors, liver surgery, prostatectomy, and vascular procedures.
    • High mortality rate (two-thirds) observed, with half succumbing to irreversible hemorrhagic shock.
    • Secondary causes of death encompassed clotting disturbances, renal failure, and infections.

    Findings:

    • Hyperbilirubinemia and hypokalemia occurred in approximately 50% of transfused patients.
    • Effective management requires continuous blood volume substitution.
    • Therapeutic strategies should include heated/filtered blood, heparinization, and balanced clotting factor replacement.

    Implications:

    • Highlights the severe risks and challenges associated with massive transfusion protocols.
    • Emphasizes the need for prompt and comprehensive management strategies to improve survival rates.
    • Informs clinical practice regarding the critical components of managing massively bleeding patients.

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