Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reference interval for maternal serum alpha-fetoprotein.

B Norgaard-Pedersen, P Schultz-Larsen

    Clinical Genetics
    |March 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Elevated fetal steroidogenic activity in autism.

    Molecular psychiatry·2014
    Same author

    Neonatal levels of neurotrophic factors and risk of autism spectrum disorders.

    Acta psychiatrica Scandinavica·2012
    Same author

    Expanding the range of ZNF804A variants conferring risk of psychosis.

    Molecular psychiatry·2010
    Same author

    Storage policies and use of the Danish Newborn Screening Biobank.

    Journal of inherited metabolic disease·2007
    Same author

    The relation of germ cells per tubule in testes, serum inhibin B and FSH in cryptorchid boys.

    Pediatric surgery international·2006
    Same author

    Pre-treatment prediction of chemoresistance in second-line chemotherapy of ovarian carcinoma: value of serological tumor marker determination (tetranectin, YKL-40, CASA, CA 125).

    The International journal of biological markers·2006
    Same journal

    A Second Report of a Missense Variant in AMMECR1 Causing Midface Hypoplasia, Hearing Impairment, Elliptocytosis, and Nephrocalcinosis: Case Report and Literature Review.

    Clinical genetics·2026
    Same journal

    From Pathogenicity to Mechanism: A Variant Interpretation Framework for Monogenic Epilepsy.

    Clinical genetics·2026
    Same journal

    Biallelic Variants in ATP1A4 Are Associated with Oligoasthenoteratozoospermia and Male Infertility.

    Clinical genetics·2026
    Same journal

    Diagnostic Yield and Clinical Impact of Comprehensive WES/WGS Testing Beyond Common Genetic Causes in Hereditary Optic Atrophy.

    Clinical genetics·2026
    Same journal

    Further Support of Autosomal Recessive CSF3-Related Severe Congenital Neutropenia.

    Clinical genetics·2026
    Same journal

    Biallelic TMEM126B Variants as a Novel Cause of Kidney Failure-Implications for Mitochondrial Genetic Testing in Nephrology: A Response Letter.

    Clinical genetics·2026
    See all related articles

    Serial maternal serum alpha-fetoprotein (AFP) measurements in normal pregnancies closely matched established reference intervals. This highlights the utility of tracking AFP levels for detecting potential neural tube defects (NTDs).

    Area of Science:

    • Obstetrics and Gynecology
    • Clinical Chemistry
    • Prenatal Diagnostics

    Background:

    • Maternal serum alpha-fetoprotein (AFP) screening is a key component of prenatal care.
    • Established reference intervals for AFP are crucial for accurate interpretation of screening results.
    • Understanding longitudinal AFP patterns can enhance diagnostic capabilities.

    Purpose of the Study:

    • To compare serial maternal serum AFP concentrations in normal pregnancies with existing reference intervals.
    • To evaluate the clinical value of serial AFP measurements in diagnosing suspected neural tube defects (NTDs).

    Main Methods:

    • Maternal serum AFP levels were quantified in 237 samples from 28 normal pregnancies.
    • Individual AFP concentration curves were graphically compared to a published non-parametric 90% reference interval.

    Related Experiment Videos

  • Serial AFP values were analyzed in a case involving acrania and spina bifida.

    • Main Results:

    • The longitudinal AFP patterns from normal pregnancies showed strong similarity to the established reference area.
    • Maternal serum AFP values before and after a termination for acrania and spina bifida demonstrated significant changes.
    • Serial AFP quantitation proved valuable in a suspected neural tube defect case.

    Conclusions:

    • Serial maternal serum AFP measurements in normal pregnancies align well with existing single-sample reference intervals.
    • The study supports the value of serial AFP monitoring for improved detection of neural tube defects.
    • Longitudinal AFP profiling offers a valuable adjunct in prenatal screening for NTDs.