Response of anamnestic IgA-producing cells in the mouse gut after repeated intragastric immunization

1) Repeated intragastric immunization after a 90-day interval results in a local immunologic memory. 2) Repeated intragastric immunization does not induce the same circulation of gut lymphocytes as does the initial oral immunization. 3) Measurement of circulating antibodies is a poor criterion for gauging the local immune status. 4) A gastric intubation dose of 4 X 10(9) SRBC given daily for 4 days appears to be suboptimal for the induction of a local immune response.