The significance of secretory IgA in middle ear fluid

Studies of immunoglobulin levels in middle ear fluid in children with chronic otitis media show that MEF (middle ear fluid) IgA levels are proportionately higher than serum levels. Disproportionately elevated MEF IgA levels may be due to secretory IgA. Finding secretory IgA in MEF suggests the presence of a secretory epithelium and may define the etiology of chronic inflammation. Resolution of the secretory epithelium may be hastened with adequate ventilation of the middle ear space.