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Related Experiment Videos

Plasma hormone profile in anovulation.

C H Wu, G Mikhail

    Fertility and Sterility
    |March 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Hormone levels in anovulatory women varied by diagnosis. Low FSH was common, while high LH indicated polycystic ovarian disease. Estrogen deficiency marked hypothalamic and postpartum amenorrhea.

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    Area of Science:

    • Reproductive Endocrinology
    • Gynecology
    • Clinical Biochemistry

    Background:

    • Anovulation presents a complex endocrine challenge in reproductive medicine.
    • Understanding hormonal profiles is crucial for diagnosing and managing anovulatory disorders.
    • Previous studies have highlighted specific hormonal imbalances, but comprehensive daily monitoring across diverse anovulatory conditions is less explored.

    Purpose of the Study:

    • To investigate daily plasma hormone fluctuations in various subtypes of anovulatory patients.
    • To correlate specific hormone levels (LH, FSH, E1, E2, progesterone, androstenedione, T) with distinct clinical diagnoses.
    • To identify potential hormonal markers for different anovulatory conditions.

    Main Methods:

    • Daily plasma hormone levels (LH, FSH, E1, E2, progesterone, androstenedione, T) were measured over 3-4 weeks in 16 anovulatory patients.

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  • Patients were categorized by clinical diagnoses including anovulation-eumenorrhea, -polymenorrhea, -oligomenorrhea, congenital adrenal hyperplasia, polycystic ovarian disease, severe hypothalamic amenorrhea, and postpartum amenorrhea-galactorrhea.
  • Clinical observations of follicular activity and menstrual patterns were recorded.

    • Main Results:

    • Follicular activity and estrogen withdrawal bleeding were observed in polymenorrheic and oligomenorrheic patients.
    • Anovulation-eumenorrhea patients showed no follicular maturation, with menstruation attributed to breakthrough bleeding.
    • Low FSH levels were noted in anovulatory patients with eumenorrhea, polymenorrhea, and oligomenorrhea.
    • Significantly high LH levels were associated with polycystic ovarian disease (classic and non-classic).
    • Extremely low estrone (E1) and estradiol (E2) levels were found in severe hypothalamic amenorrhea and postpartum amenorrhea-galactorrhea.
    • Elevated testosterone (T) levels correlated with hirsutism.
    • Slightly elevated progesterone levels before menstruation were linked to LH surges in polymenorrheic and oligomenorrheic patients.

    Conclusions:

    • Distinct hormonal profiles characterize different anovulatory conditions, aiding in diagnosis.
    • LH and FSH levels serve as key indicators for polycystic ovarian disease and other anovulatory states.
    • Estrogen deficiency is a hallmark of severe hypothalamic and postpartum amenorrhea.
    • Hormonal monitoring provides valuable insights into the pathophysiology of anovulation and associated symptoms like hirsutism.