Differential antibody forming cell response in mice due to levamisole treatment

The administration of varying doses of levamisole on the antibody forming cell (AFC) response of C57BL6/J mice to sheep red blood cells was investigated. Doses of 0.5 and 2.5 mg/kg potentiated the AFC response, while a dose of 5 mg/kg levamisole blocked the AFC response. Injection of the latter does of levamisole one day after antigen exposure did not inhibit the AFC response. Levamisole did not alter the basal response to sheep red blood cells of otherwise untreated mice.