[Encephalopathy due to vincristine sulfate (author's transl)]

A cytotoxic effect by vincristine sulfate on the cerebral cortex is claimed in literature. In 188 children treated with vincristine we saw no so called "Vincristine-induced Encephalopathy". The proportional risk of vincristin-induced cerebral complications amount to 1%, as demonstrated by various authors. In 67 children investigated 5 weeks up to 2 years after last vincristine-injection we found no EEG-tracing, which could be discussed as a vincristine-induced finding.