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Construction and function of a new hydraulic cuff occluder.
Pflugers Archiv : European Journal of Physiology
|May 15, 1979
Summary
A novel vascular cuff occluder enables safe, controlled vessel occlusion in conscious animals. This implantable device offers precise pressure control and can be reused after sterilization, advancing preclinical research.
Area of Science:
- Biomedical Engineering
- Surgical Devices
- Animal Models
Background:
- Vascular occlusion is crucial for various preclinical studies.
- Existing methods may lack precision, safety, or reusability.
- Conscious animal models require minimally invasive and reliable occlusion tools.
Purpose of the Study:
- To describe the construction of a new vascular cuff occluder.
- To highlight features enabling safe and controlled vessel occlusion.
- To present a device suitable for long-term implantation and repeated use in conscious animals.
Main Methods:
- Design and construction of a novel vascular cuff occluder.
- Incorporation of an extrathoracic pressure control system.
- Evaluation of occlusion safety, pressure control, and long-term implantability.
Main Results:
- The occluder provides safe and complete vessel occlusion.
- Definite cuff pressure is maintained via extrathoracic control.
- The device demonstrates long-term implantability and suitability for multiple uses and sterilization.
Conclusions:
- The new vascular cuff occluder is a safe and effective tool for preclinical research.
- Its features facilitate precise, reproducible vascular occlusion in conscious animal models.
- The device's reusability and implantability enhance its utility and cost-effectiveness.