Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Central noradrenergic--cholinergic interaction and locomotor behavior.

S T Mason

    European Journal of Pharmacology
    |June 1, 1979
    PubMed
    Summary

    Forebrain noradrenaline depletion blocked catalepsy induced by arecoline and enhanced scopolamine

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Chronic administration of type A monoamine oxidase inhibitors increases duration of thiopentone anaesthesia in the rat.

    Physiology & behavior·1985
    Same author

    Chronic and acute administration of typical and atypical antidepressants on activity of brain noradrenaline systems in the rat thiopentone anaesthesia model.

    Psychopharmacology·1984
    Same author

    Brain noradrenaline and anaesthesia: further characterization of the beta-receptor.

    Neuropharmacology·1983
    Same author

    Brain noradrenaline and anaesthesia: behavioural and electrophysiological evidence.

    Neuroscience·1983
    Same author

    Anaesthesia: the role of adrenergic mechanisms.

    European journal of pharmacology·1983
    Same author

    Brain noradrenaline and varieties of alternation learning.

    Behavioural brain research·1983

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Neurochemistry

    Background:

    • Cholinergic and noradrenergic systems are crucial for regulating brain functions, including arousal and motor activity.
    • Interactions between these neurotransmitter systems are complex and not fully understood, particularly concerning their roles in specific behavioral states like catalepsy and locomotor stimulation.
    • Understanding these interactions can provide insights into neurological disorders affecting arousal and movement.

    Purpose of the Study:

    • To investigate the role of forebrain noradrenaline in modulating the effects of cholinergic drugs on behavior.
    • To determine if noradrenergic depletion affects responses to muscarinic and nicotinic cholinergic agents.
    • To elucidate the nature of noradrenergic-cholinergic interactions in the brain.

    Main Methods:

    • Depletion of forebrain noradrenaline in cats using intracerebral injections of 6-hydroxydopamine into the dorsal noradrenergic bundle.
    • Administration of muscarinic cholinergic agonist (arecoline) and blocker (scopolamine) to assess behavioral changes.
    • Administration of nicotinic drugs (mecamylamine and nicotine) to evaluate their effects post-noradrenaline depletion.

    Main Results:

    • Depletion of forebrain noradrenaline significantly blocked the cataleptic effects induced by the muscarinic agonist arecoline.
    • Locomotor stimulant effects of the muscarinic blocker scopolamine were potentiated following noradrenaline depletion.
    • The actions of nicotinic drugs, mecamylamine and nicotine, remained unaffected by the forebrain noradrenaline depletion.

    Conclusions:

    • A functional interaction between noradrenergic and muscarinic cholinergic systems in the brain exists.
    • This interaction appears to play a role in the central control of arousal, influencing states from catalepsy to locomotor stimulation.
    • Nicotinic cholinergic pathways do not seem to be modulated by forebrain noradrenaline in the context of these behaviors.

    Related Experiment Videos